孙逊 教授 (博士，博士生导师)
单位：澳门官方游戏网站药剂教研室
通讯地址：成都市人民南路三段17号澳门官方游戏网站
电话/传真：（028）85502307
E-mail: sunxun@scu.edu.cn，xunsun22@gmail.com
简历
现任澳门官方游戏网站教授，博士生导师，药剂学系主任，国家杰出青年科学基金获得者,国家药典委员会委员，国家优秀青年基金获得者，英国皇家学会牛顿高级学者，四川省学术和技术带头人，四川省高级留学回国人员。
1991.9-1996.7 华西医科大学澳门官方游戏网站本科
1996.8-2000.7 第一军医大学珠江医院
2000.9-2005.7 澳门官方游戏网站攻读药剂学博士学位
2005.8-2007.2 美国宾夕法尼亚大学医学院博士后
2007.2-2008.9 美国密西根大学澳门官方游戏网站博士后
2008.9-2012.6 澳门官方游戏网站副研究员
2012.7-今 澳门官方游戏网站教授
研究方向
1.生物大分子药物高效递释系统。
2.靶向药物传递系统和分子药剂学。
学术兼职
国家药典委员会委员（生物制品专业）
美国基因和细胞治疗协会（ASGCT)官方杂志Molecular Therapy （IF=8.9）副主编
药剂学排名第一的SCI期刊J. Controlled Release（IF=7.7）副主编
《药学学报》英文刊(Acta Pharmaceutica Sinica B，IF 7.0)编委
美国基因和细胞治疗协会Nanoagents & Synthetic Formulations专业委员会委员
中国药学会药剂专业委员会委员
四川省药学会副秘书长和常务理事
四川省药学会生物药物专业副主任委员
《中国工业医药杂志》编委
科研成果获奖情况：
1)2017年荣获树兰医学青年奖
2)2015年荣获四川省科技进步一等奖（第5完成人）；获奖题目：中药新型给药系统的示范研究与应用
3)2015年荣获第三届四川省卫计委有突出贡献的中青年专家荣誉称号
4)2014年荣获成都市科学技术进步奖二等奖；获奖题目：中药新型给药系统的示范研究与应用（第5完成人）
5)2012年获“中国药学会青年药剂奖”
6)2011年荣获第十一届四川省青年科技奖
7)2011年荣获四川省科技进步一等奖 （第3完成人）；获奖题目：针对多种器官组织或细胞的靶向释药系统的构建、表征及靶向特性研究
8)2008年获全国百篇优秀博士学位论文提名奖，获奖题目：静脉注射用治疗基因靶向传递系统研究
9)2006年荣获四川省科技进步三等奖（第2完成人）；获奖题目：治疗基因靶向传递系统的研究
主持的科研项目：
主持国家自然科学基金8项，国际合作项目3项，教育部新世纪优秀人才计划1项，国家科技重大专项子课题1项，四川省重大科技专项1项。
1.国家自然科学基金杰出青年基金, 81925036, 生物大分子药物递释系统, 2020/01-2024/12,400万元。
2.国家自然科学基金国际(地区)合作与交流项目,81961130395, 新型无痛缓释型乙肝疫苗微针的基础开发及应用, 2019/03-2022/02,49万元。
3.国家自然科学基金面上项目, 81872814, 靶向淋巴结内树突状细胞的疫苗递送系统用于类风湿性关节炎的治疗, 2019/01-2022/12,57万元。
4.四川省重大科技专项, 2018SZDZX0018,基于可注射天然来源辅料的微粒递药系统的构建及其应用, 2018/07-2021/09,200万元。
5.国家自然科学基金面上项目, 81673362, 克服免疫抑制屏障的多功能肿瘤疫苗载体的构建及其机制研究, 2017/01-2020/12,60万元。
6.国家自然科学基金优秀青年基金, 81422044, 药剂学, 2015/01-2017/12,100万元。
7.国家自然科学基金面上项目，81173011，跨越肿瘤递送屏障的多功能腺病毒载体系统的研究，2012/1-2015/12, 60万元。
8.四川省青年科技基金，2012JQ0024，高效安全的小核酸干扰药物传递系统的研究，2012/01-2014/12，10万元。
9.国家科技重大专项子课题，2011ZX09401-304(4-3)，基因传递系统关键技术研究，2011/01-2013/12，60.5万元。
10.与英国中央兰开夏大学合作项目, 11H1554, Nanomedicines for Drug Delivery Applications of anticancer small molecule, gene and protein，140万元，2011/11-2014/12。
11.教育部新世纪优秀人才支持计划，NCET-10-0601，2010/01-2012/12，50万元。
12.国家自然科学基金面上项目，30973657，基于载体构-效关系设计的多功能高效肺靶向siRNA传递系统研究，2010/01-2012/12，34万元。
13.欧盟第七框架项目资助的科研项目，PIRSES-GA-2008-230791，Hyaluronan-based injectable material for tissue engineering，2009/09-2013/08，8.7万欧元。
14.国家自然科学基金青年基金，30600786，呼吸道粘膜上皮细胞靶向基因传递系统研究，2007/01-2009/12，24万元。
15.四川省重点科技攻关项目，05SG022-019-2, IL-12基因纳米脂质体注射剂的研究,2006/01-2008/12,5万元。
Prof. Dr. Xun Sun
Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education
Department of Pharmaceutics
West China School of Pharmacy
Sichuan University, Chengdu 610041, China
Tel/Fax: (+86) 28 85502307
E-mail: sunxun@scu.edu.cn，xunsun22@gmail.com
Prof. Xun Sun is the Director & Professor of Department of Pharmaceutics, West China School of Pharmacy, Sichuan University. After postdoctoral training at University of Pennsylvania and University of Michigan, she joined the faculty of Sichuan University in 2008 and became a Professor in 2012. Prof. Sun’s current research centers on the delivery of biopharmaceuticals, especially for vaccines and nucleic acid based therapeutics. She has published more than 70 peer-reviewed papers as the corresponding author. She filed 22 patents and contributed chapters to 8 books. She is the Associate Editor of Journal of Controlled Release， Molecular Therapy and Pharmaceutical Fronts. She also serves as the editorial board member of and Acta Pharmaceutica Sinica B and the member of Chinese Pharmacopoeia Commission. Prof. Sun was the recipient of the National Science Fund for Distinguished Young Scholars, the Royal Society Newton Advanced Fellowship (UK), the Nagai Foundation Tokyo International Scholarship, the Shulan Medical Prize, the first Prize of Sichuan Provincial Science and Technology Improvement Prize, Sichuan Youth Award for Science and Technology.
Selected Publications (代表性论著)
More publication can be found in https://orcid.org/0000-0002-0218-1664
1.Xiaoyu Hong, Xiaofang Zhong, Guangsheng Du, Yingying Hou, Yunting Zhang, Zhirong Zhang, Tao Gong, Ling Zhang*, Xun Sun*, The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency, Science Advances. IF 12.804, 2020, 6 : eaaz4462
2.Wenfei Chen, Zhaofei Guo, Yining Zhu, Nan Qiao, Zhirong Zhang, and Xun Sun*, Combination of Bacterial-Photothermal Therapy with an Anti-PD-1 Peptide Depot for Enhanced Immunity against Advanced Cancer, Adv. Funct. Mater. IF 15.621, 2019, 1906623
3.Qin Wang, Yan Li, Xiaoyan Chen, Hao Jiang, Zhirong Zhang, and Xun Sun*, Optimized in vivo performance of acid-liable micelles for the treatment of rheumatoid arthritis by one single injection, Nano Research, IF 8.515, 2019, 12(2): 421–428
4.Wenfei Chen, Ying Wang, Ming Qin, Xudong Zhang, Zhirong Zhang, Xun Sun*, Zhen Gu. Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy, ACS nano, IF 13.903, 2018;5995-6005
5.Yuandong Zhang, Haibo Li, Qin Wang, Xinyan Hao, Hanmei Li, Heqiang Sun, Lu Han, Zhirong Zhang, Quanming Zou,* and Xun Sun*, Rationally Designed Self‐Assembling Nanoparticles to Overcome Mucus and Epithelium Transport Barriers for Oral Vaccines against Helicobacter pylori. Advanced Functional Materials, IF 15.621, 2018: 1802675
6.Mengke Qu, Qing Lin, Luyi Huang, Yao Fu, Luyao Wang, Shanshan He, Yu Fu, Shengyong Yang, Zhirong Zhang, Ling Zhang*, Xun Sun*, Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease, Journal of Controlled Release, IF 7.901, 2018; 287: 156-166 （Highly cited paper）
7.Zhonghua Ji, Zhaolu Xie, Zhirong Zhang, Tao Gong, Xun Sun*, Engineering intravaginal vaccines to overcome mucosal and epithelial barriers, Biomaterials. IF 10.273, 2017;128,8-18
8.Hao Jiang, Qin Wang, Lin Li, Qin Zeng, Hanmei Li, Tao Gong, Zhirong Zhang, Xun Sun* Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8+ T Cell Responses. Advanced Science, IF 15.804 , 2018; 5, 1700426 (Front cover paper)
9.Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun*, Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines, Biomaterials. IF 10.273,2017;122,105-113
10.Qin Wang, Hao Jiang, Yan Li, Wenfei Chen, Hanmei Li, Ke Peng, Zhirong Zhang, Xun Sun*, Targeting NF-kB Signaling With Polymeric Hybrid Micelles That Co-Deliver siRNA and Dexamethasone for Arthritis Therapy, Biomaterials. IF 10.273,2017;122,10-22
11.Hao Jiang, Qin Wang, Xun Sun*, Lymph node targeting strategies to improve vaccination efficacy. Journal of Controlled Release, IF= 7.877 2017;267,47-56.
12.Lu Han, Jiao Xue, Luyao Wang, Ke Peng, Zhirong Zhang, Tao Gong, Xun Sun*, An injectable, low-toxicity phospholipid-based phase separation gel that induces strong and persistent immune responses in mice, Biomaterials. IF 10.273,2016;105,185-194
13.Hanmei Li, Yao Fu, Ting Zhang, Yanping Li, Xiaoyu Hong, Jiayu Jiang, Tao Gong, Zhirong Zhang, Xun Sun*, Rational Design of Polymeric Hybrid Micelles with Highly Tunable Properties to Co-Deliver MicroRNA-34a and Vismodegib for Melanoma Therapy, Adv. Funct. Mater. IF 11.382, 2015, 25, 7457-7469
14.Zhaolu Xie, Zhonghua Ji, Zhirong Zhang, Tao Gong, Xun Sun*, Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1, Biomaterials. IF 10.273, 2014; 35, 7896-7908
15.Jianfeng Han , Qin Wang , Zhirong Zhang , Tao Gong , Xun Sun*, Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer. Small, IF 10.856, 2014, 10: 3524–3535
16.Yu Wan, Jianfeng Han, Gerui Fan, Zhirong Zhang, Tao Gong, Xun Sun* Enzyme-responsive liposomes modified adenoviral vectors for enhanced tumor cell transduction and reduced immunogenicity. Biomaterials, IF 10.273,2013;34,3020-3030
17.Qiang Peng, Zhi-Rong Zhang, Tao Gong, Guo-Qiang Chen,* Xun Sun,*A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles, Biomaterials, IF 10.273, 2012; 33, 1583-1588
18.Sanjun Shi, Lu Han, Tao Gong, Zhirong Zhang, Xun Sun*, Systemic delivery of microRNA
-34a
for cancer stem cell therapy
. Angewandte Chemie International Edition, IF 11.336, 2013, 52: 3901-3905.
