参加工作以来，一直从事药物合成及有机合成工作。先后进行过抗菌素单环β-内酰胺类的合成研究，肝胆显影剂、脑显影剂的合成、抗肿瘤药物——小檗碱、磺酰腙类、芳维甲酸类衍生物、有机锗化合物、磷脂醚类……等衍生物的合成及生物活性研究，抗癌新药米托蒽醌的合成研究，天然产物信息素的全合成及酶催化不对称合成研究，天然甾体衍生物的提取、分离、鉴定，以及相关甾体酶抑制剂的合成，催化反应的研究。
2002年“214重点人才工程计划”第三层次人才。2008年四川省卫生厅学术带头人。曾获四川省教学成果一等奖；澳门官方游戏网站教学成果一等奖；化学制药工艺学实习优秀指导教师二等奖；化学制药工艺学教学成果二等奖；1992-1993年度优秀青年教师。获全国发明展览会及四川省发明展览会优秀奖。卫生部科学技术进步三等奖；四川省教育委员会科学技术进步人文社会科学科研成果二等奖；四川省科技进步二等奖；四川省科技进步三等奖。先后在国内外学术刊物上发表科研论文40余篇，其中本专业领域期刊如Org.Lett.；E.J. Org. Chem.; E. J. Med. Chem.；Bioorg. & Med. Chem. Lett.；SynLett.；Synthesis；J. Mole. Cataly. A:Chemical.等共发表SCI论文25篇；授权专利2项。参编学术专著一部《抗癌药物设计》。
先后负责过澳门官方游戏网站校青年基金资助的"新型不对称均相催化剂的研究"；"一个甾体基本骨架的多方位应用研究"，以及澳门官方游戏网站给予的多项启动基金的资助。主研国家自然科学基金资助的"抗癌药物合成及构效关系的研究"、"国产抗癌新药DHAQ的研究"、"用反Diels-Alder反应合成蚁皇识别信息素及其有关物"、"磷脂醚类化合物亲肿瘤性技术研究"、“肿瘤早期诊断剂的合成及应用研究”。负责广东省教育部产学研结合项目“一种心血管创新药物丙丁酚单琥珀酸酯的研究开发”等研究工作，并负责了多项企业合作项目的研究，如：抗糖尿病药物的合成及构效关系研究；头孢类抗生素的合成研究等。
1. Nan Liu, Bo-Yang Tang, Yue Chen, Li-Juan Chen, Ling He*. Catalyzed Imidation of Tertiaryamine by Simple Copper Salt. Europing Journal of Organic Chemistry 2009, 2059~2062.
2. Yan Jiang, Guo-Chuan Zhou, Guang-Li He, Ling He*, Ju-Lian Li, Shi-Long Zheng. Ruthenium (II) Porphyrin-Catalyzed Selective N-Imidation of Aromatic Nitrogen Heterocycles. Synthesis, 2007, 10, 1459~1464.
3. Zhuan Fang, Guo-Chuan Zhou, Shi-Long Zheng, Guang-Li He, Ju-Lian Li, Ling He*, Di Bei. Lithium chloride-catalyzed selective demethylation of aryl methyl ethers under microwave irradiation. Journal of Molecular catalysis A:Chemical. 2007, 274, 16~23.
4. Ling He, Jing Yu, Ji Zhang, Xiao-Qi Yu*. Catalyzed Amidation of Cyclic Ethers by Simple Copper Salt and Preparation of Aminoalcohols. Organic Letters, 2007. 9（12）2277~2280.
5. Ling He, Qin Wang, Guo-Chuan Zhou, Lei Guo, Xiao-Qi Yu*. Copper-Catalyzed Cleavage of Benzyl Ethers with DiacetoxyiodoBenzene and p-Toluenesulfonamide. Arkivoc, 2008；xii：103-108.
6. Ling He，Philip Wai Hong, Wai-Man Tsui, Wing-Yiu, and Chi-Ming Che*. Ruthenium (II)Prophyrin-Catalyzed Amidation of Aromatic Heterocyclic. Organic Letters, 2004, 6 (14), 2405~2408.
7. Ling He*，Ju-lian Li, Jian-Jun Zhang, Pu Su and Shi-Long Zheng. Microwave assisted synthesis of melatonin. Synthetic Communications, 2003，33，741.
8. Ling He*, He Xi Chang, Ting Chao Chou,Niramol Savaraj,C. C. Cheng*. Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern -synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives. European Journal of Medicinal Chemistry, 2003, 38,101-107.
9. Yu Jing, Zhang Wen Wen,Li Ying Hong,Li Sheng Nan, He Ling*. Asymmetric Synthesis of Nebivolol. Chinese Journal of Organic Chemistry 2008; 28 (3): 511-514.
10. Xiao-Ai Wu, Ping Ying, Jun-Yang Liu, Heng-Shui Shen, Yue Chen, Ling He*. Lithium chloride-catalyzed selective 'hydrolysis' of methyl esters under microwave rradiation. Synthetic Communications, 2009，in press
11. Xin-Feng Luo, Ling He*, Hai-Bin Yin, Hu Zheng, Di Bei, Jin-Jin Deng, Wen-Cai Huangc*. Efficient Acylation and One-Pot Synthesis of Dehydroandrographolide Succinate on a Large Scale Assisted with Microwave Radiation. Synthetic Communications, 2009，in press.
12. Zhi Yu Liu*, Ling He, Hu Zheng. Highly Enantioselective synthesis of (+) and (-) Endo-Tricyclo[5,2,1,02,6] Deca-4,8-dien-3-one and (-)-4-t-Butyldimethyl silyloxycyclopentenone by Enzyme-catalyzed Acetylation. Tetrahedron: Asymmetry 1993, 4, 2277-2278.
13. Zhi Yu Liu*, Ling He, Hu Zheng. Natural Products Synthesis by Retro Diels-Alder Reactions IV: Total Synthesis of invictolide and 6-Epiinvictolide. SYNLETT , 1993, 191-192.
14. W.David Nes*, Ling He, Anil T. Mangla. 4,4,14α-Trimethyl 9β,19-cyclo-5α-26-Homoch- olesta-24,26-Dien-3β-ol:A Potent Mechanism-Based Inactivator of △24(25) To △25(27) Sterol Methyl Tran- sferase. Bioorganic & Medicinal Chemistry Letters 1998, 8, 3449-3452.
15. Xiaohong Ou, Tianzhi Tan, Ling He, Yunchun Li,Julian Li,Anren Kuang. Antitumor effects of radioiodinated antisense oligonuclide mediated by VIP receptor. Cancer gene therapy 2005, 12(3), 313-20.
16. Yue Chen*, Zhan Wen Huang, Ling He, Shi Long Zheng, Ju Lian Li, Da Lian Qin. Synthesis and evaluation of a technetium-99m-labeled diethylene triaminepentaacetate- deoxyglucose complex ([99mTc]-DTPA-DG) as a potential imaging modality for tumors. Applied Radiation and Isotopes 2006, 64(3), 342-347.
17. Yue Chen*, Zhan Wen Huang, Ling He, Ju Lian Li, Da Lian Qin. Synthesis and Characterization of 99mTc-DTPA-DG for Tumor Detection. European Journal of Nuclear Medicine and Molecular Imaging 2005, Vol.32.771.
18. Zhi Yu Liu*,Xin Jie Chu, Ling He, Yi Long Xie, Natural Products Synthesis by Retro Diels-Alder Reaction (Review), Organic Chemistry, 1997,17(1), 62-65.
19. W. David Nes*,Julie A.Marshall,Wen Zhou, Ling He, Allen L. Dennis. Mechanism-Based Active Site Modification of Sterol Methyl Transferase by Tritium-Labeled 26-Homocholesta-8,14,24-Trien-26-yn-3β-ol. Tetrahedron letters, 1998, 39: 8575~8578.
20. W.David Nes*,Brian S. McCourt,Julie A. Marshall,Jian Zhong Ma,Allen L. Dennis,Monica Lopez,Hao Xia Li, Ling He. Site-Directed Mutagenesis of Sterol Methyl Transferase Active Site From Saccharomyces Cersvisiae Results in Formation of Novel-Ethyl Sterols. J.Org.Chem. 1999, 64(5), 1535-1542.
21. 发表于中文核心期刊的文章略
